Lepromin skin test
The lepromin skin test is used to determine what type of leprosy a person has.
Leprosy skin test; Hansen disease - skin test
How the Test is Performed
A sample of inactivated (unable to cause infection) leprosy-causing bacteria is injected just under the skin, often on the forearm, so that a small lump pushes the skin up. The lump indicates that the
The injection site is labeled and examined 3 days, and again 28 days later to see if there is a reaction.
How to Prepare for the Test
If your child is to have this test performed, it may be helpful to explain how the test will feel, and even demonstrate on a doll. Explain the reason for the test. Knowing the "how and why" may reduce the anxiety your child feels.
How the Test will Feel
When the antigen is injected, there may be a slight stinging or burning. There may also be mild itching at the site of injection afterward.
Why the Test is Performed
This test is a research tool that helps classify the different types of leprosy. It is not recommended as the main method to diagnose leprosy.
People who don't have leprosy will have little or no skin reaction to the antigen. People with a particular type of leprosy, called lepromatous leprosy, will also have no skin reaction to the antigen.
What Abnormal Results Mean
A positive skin reaction may be seen in people with specific forms of leprosy, such as tuberculoid and borderline tuberculoid leprosy. People with lepromatous leprosy will not have a positive skin reaction.
There is a very small risk for an allergic reaction, which may include itching and rarely,
Dupnik K. Leprosy (Mycobacterium leprae). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 250.
James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Hansen disease. In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseases of the Skin. 13th ed. Philadelphia, PA: Elsevier; 2020:chap 17.
Review Date: 08/25/2019
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright ©2019 A.D.A.M., Inc., as modified by University of California San Francisco. Any duplication or distribution of the information contained herein is strictly prohibited.
Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Please discuss with your doctor any questions or concerns you may have.