Signs & Symptoms Rheumatology

Sjögren's Syndrome
Signs and Symptoms

The hallmark symptoms of Sjögren's syndrome are extreme dry eyes and mouth. Some people also experience joint pain, swelling and/or stiffness.

Sjögren's syndrome that occurs by itself is called primary Sjögren's syndrome. When it occurs with another rheumatic disease – such as rheumatoid arthritis, systemic lupus, scleroderma or polymyositis-dermatomyositis – it's called secondary Sjögren's syndrome.

Affecting as many as 4 million Americans, Sjögren's syndrome is one of the most common of the autoimmune diseases. Nine in 10 patients are women, and onset is typically in middle age. The cause of the disease is unknown, although heredity, infection and hormones may be contributing factors.

UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.

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