Your doctor will begin by recording your complete medical history, including a description of your symptoms. You also will undergo a physical examination to check for any physical signs of the disease. Although the cause is not completely understood, a gene called HLA-B27 has been shown to increase a person's chance of developing the condition after a urogenital or intestinal infection. An estimated 75 percent of people with reactive arthritis have this gene.
UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.